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the exposure of the hydroxybupropion metabolite was decreased by 23 , the threohydrobupropion decreased by 38 , and the erythrohydrobupropion decreased by 48 .

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there is evidence that bupropion s development was inspired by the structure of amphetamine, which had been used, with limited success, as an antidepressant in the 1930s.

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major bupropion is associated with a dose-related risk of seizures.
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