Nitrofurantoin is contraindicated in pregnant women at term 38-42 weeks gestation , including during labor and delivery or when onset of labor is imminent, because of the possibility of hemolytic anemia in the neonate secondary to immature enzyme systems.

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thus, the breakpoint for nitrofurantoin is set to 32 mg l, meaning that bacterial strains with mics higher than 32 mg l are defined as resistant, implying that therapy with the antibiotic should be avoided against such strains.

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3 feb 2016 the 2015 beers criteria for potentially inappropriate medication use in older adults includes an updated recommendation for nitrofurantoin; nitrofurantoin may be used for prophylaxis of recurrent urinary tract infections in women; however, this agent has been associated with acute, subacute, and; br j gen pract.

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