Combined use of methotrexate with gold, penicillamine, hydroxychloroquine, sulfasalazine, or cytotoxic agents, has not been studied and may increase the incidence of adverse effects.

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chloroquine has similar pharmacokinetics 62 ; therefore, not only the dosage but also individual differences in drug metabolism and distribution may explain the different conclusions of the aforementioned studies.

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60 kg or more 1 g chloroquine phosphate 600 mg base orally at once, followed by 500 mg chloroquine phosphate 300 mg base orally at 6, 24, and 48 hours; represents a total dose of 2.

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although data are lacking, cyp2d6 inhibitors, such as hydroxychloroquine, could potentially increase nebivolol plasma concentrations via cyp2d6 inhibition; the clinical significance of this potential interaction is unknown, but an increase in adverse effects is possible.

These reports of chloroquine-prophylaxis or treatment failures were substantiated by serial parasitologic and clinical observations of each infection and, when available, in-vitro confirmation of drug resistance.

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